Bevacizumab Treatment of Radiation-Induced Brain Necrosis: A Systematic Review
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چکیده
منابع مشابه
Bevacizumab for the Treatment of Radiation-Induced Cerebral Necrosis: A Systematic Review of the Literature
Radiation necrosis (RN) of brain tissue is a serious late complication of brain irradiation and recently bevacizumab has been suggested as treatment option of RN. There is a lack of data in the literature regarding the effectiveness of bevacizumab for the treatment of RN. The purpose of this review was to perform a comprehensive analysis of all reported cases using bevacizumab for the treatment...
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The case study reported on acquired bevacizumab resistance in one patient receiving re-treatment with bevacizumab following radiation brain necrosis progression after bevacizumab was discontinued. This case offers novel and additional insight for bevacizumab treatment. Low-dose bevacizumab is effective for radiation brain necrosis, and radiation brain necrosis may progress after bevacizumab dis...
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BACKGROUND Cerebral radiation necrosis (RN) is a difficult to treat complication of stereotactic radiosurgery (SRS) that can result in progressive neurologic decline. Currently, steroids are the standard of care treatment for brain RN despite their adverse effect profile and limited efficacy. The purpose of this study was to evaluate the treatment efficacy of cerebral RN to bevacizumab in patie...
متن کاملLow-Dose Bevacizumab Is Effective in Radiation-Induced Necrosis
BACKGROUND Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited. METHODS The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported. RESULTS Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. ...
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Radiation-induced normal tissue lesions, once seen as a consequence of loss of proliferative integrity of clonogenic target cells, inevitable and untreatable are now viewed as a result of dynamic interactions between multiple cell lines within a particular tissue that can be intervened. Normal tissue damage is the most important limiting factor in radiotherapy and a major component in the medic...
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ژورنال
عنوان ژورنال: Frontiers in Oncology
سال: 2021
ISSN: 2234-943X
DOI: 10.3389/fonc.2021.593449